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Soft Matter & Self-Assembly

Joint Workshop in De Witte Vosch, Utrecht, 19 January 2023

Soft Matter & Self-Assembly

Joint 4TU.HTM, M2i & Zernike Institute for Advanced Materials workshop. We invited scientists with interest and expertise in soft matter including its assembly, to exchange knowledge, and explore ways of collaboration.

This event took place as an all-day live event in De Witte Vosch, Utrecht on Thursday 19 January 2023. Pictures and presentations can be found on this website.

Full Programme: Soft Matter & Self-Assembly
(Pdf file)

Check the presentations given by
Jasper van der Gucht (WUR)
Wiebe de Vos (UTwente)
Georgy A. Filonenko (TU Delft)
Julien Es Sayed (RUG)
Emma Hinderink (TU Delft)
Siddharth Desphande (WUR)
Janne-Mieke Meijer (TU/e)

Atze Jan van der Goot (WUR) and Julieta Paez (UT) refer to their articles for further info.

For more information: Reina Boerrigter (Coordinator 4TU.HTM)

Aim of the worshop
Soft matter surrounds us in our daily lives, and are omni-present i.e., foods, polymers, plants, humans. Often these materials are formed through a complex sequence of self-assembly processes. In this workshop we did not only highlight the importance of soft matter materials in addressing societal challenges, we also elaborated on their underlying mechanism through a dedicated line-up of researchers.

Programme
The programme consisted of presentations and plenary discussions on the following topics:

Emulsions, Adhesives, Polymeric layers, Self-Assembly
Fundamental aspects versus Applications

Prof.dr.ir. Jasper van der Gucht - keynote speaker

Professor of Physical Chemistry and Soft Matter, WUR

Presentation
When gels become unstable: yielding and syneresis in colloidal networks (Pdf file, 15 MB)

With his group Jasper van der Gucht works on soft networks, gels, and composite materials that are formed by the spontaneous organization (or self-assembly) of macromolecules or colloidal particles. In this lecture, Jasper will focus on colloidal gels, networks formed by attractive particles or droplets. Such networks are abundant in household products, foods, and ceramics. In particular he will discuss recent results on the stability of such gels, under external stress (yielding) or under the internal stresses that arise during gelation (syneresis).   

Prof.dr.ir. Wiebe de Vos

Professor of Membrane Surface Science, UTwente

Presentation
Asymmetric polyelectrolyte multilayers for clean water production (Pdf file, 2 MB)

Abstract
Within his group Prof. de Vos successfully combines his background in the fundamentals of colloid and surface science with the much more applied field of membranes. His work in encompasses the coating of membranes for various functional enhancements, including anti-fouling, enhanced separations, easy-to-clean membranes and virus in-activation, but also entails the production of membranes using sustainable approaches such as aqueous phase separation. In this talk, the focus will be on how smart application of polyelectrolyte multilayers can allow the fabrication of highly promising membranes, that effectively remove small organic pollutants from water.




References

Check this eye-opener by Wiebe de Vos!
(In Dutch: Slim membranen maken; in water)

Dr. Siddharth Deshpande

Assistant Professor in Emergent Biological Systems, Laboratory of Physical Chemistry and Soft Matter, WUR

Presentation
Crystal-Gazing: Biosensing using colourful liquid crystals (Pdf file, 23 MB)

Abstract
In this talk, I will narrate our recent attempts to use liquid crystal droplets as microsensors to sense amphiphiles. We utilize chiral nematic liquid crystal microdroplets, which show strongly reflected structural colours, as sensing platforms. We systematically quantify the optical response of closely related biological amphiphiles and find unique optical signatures for each species. We show lab-on-a-chip capability of our method by drying droplets in two-dimensional arrays and hydrating the chip to detect dissolved analytes. Finally, we show proof-of-principle in vivo biosensing in the intestinal tracts of live zebrafish larvae, where the droplets show a clear optical response in healthy and inflamed tissues. Our results show the potential of liquid crystals in developing detection platforms and for in vivo detection of biomolecules.

Reference
L.W. Honaker, C. Chen, F.M.H. Dautzenberg, S. Brugman, and S. Deshpande*. ‚ÄúBuilding biological microsensors with chiral nematic liquid crystal droplets‚Ä̬†ACS Applied Materials and Interfaces, 14(33):37316-37329, 2022

Siddharth Deshpande is an interdisciplinary scientist fascinated by living systems. His passion is to understand how biomolecules self-assemble into functional structures and utilize these fundamental principles for bioengineering. His interests and expertise lie in biological soft matter (particularly liquid-liquid phase separation and membranes), synthetic biology, and on-chip microfluidic technology.

Check his work and group at the website:
https://siddharthdeshpandelab.com/




Follow Siddhart on Twitter: @SiddhuLab

Armin Amirsadeghi, MSc

PhD Student, Polymer Science, Faculty of Science and Engineering, RUG
Title: Biopolymer complex coacervate 3D printable Bioink

Armin works with Prof. Marleen Kamperman. Their group uses biologically inspired strategies to develop polymeric materials for underwater adhesives and functional materials. 

Check the eye-opener by Marleen Kamperman (RUG): Glue inspired by nature

Dr. Georgy A. Filonenko

Assistant Professor in Polymers & Soft Materials, Materials Science and Engineering Department, TU Delft

Presentation
Molecular mechanochemistry for optical imaging of internal stresses in polymer films (Pdf file, 4 MB)

Abstract
When polymers solidify they accumulate internal tensile and compressive stresses in their bulk and surface. These stress patterns affect mechanical performance of polymer devices. In the case of thin films they are one of the main reasons for defect formation and delamination. Few optical and spectroscopic methods for estimating internal stresses exist and they generally reflect macroscopic alignment, density or other physical aspects of the sample. In our work we use chemical reactions to track internal stresses. Since our feedback signal originates on the level of molecules we can perform structural studies using our technique. Being able to label any discrete location within the polymer, we could also examining the effects which topology has on stress perception. Ultimately, chemistry is our main tool in manipulating polymers and with current techniques we can start examining its molecular manifestations within real macroscopic materials.

Contact
Georgy A. Filonenko is an experimental physical chemist with expertise in polymers, soft matter and sensing. He studies internal stresses in polymeric films. Follow him on Twitter: @GeorgyFilonenko, and LinkedIn

Dr. Julien Es Sayed

Postdoc Polymer Science, Zernike Institute of Advanced Materials, Science & Engineering, RUG

Presentation
Smart Emulsions using Responsive Pickering Emulsifiers (Pdf file, 2 MB)

Abstract
Pickering emulsions are emulsions stabilized by colloidal particles that are known to exhibit a high kinetic stability which make them promising candidates for a wide range of applications where long term storage is needed. However, when it comes to the development of so-called ‚Äúsmart emulsions‚ÄĚ for which the destabilization of the emulsion and the release of the active components present in the dispersed phase should be triggered by an external stimulus, this high stability can become detrimental. In this talk, I will introduce the audience to two innovative Pickering emulsifiers that we designed which enable us to develop kinetically stable emulsions but which can be at the same time readily destabilized by action of an external stimulus.



References

Contact
Julien Es Sayed (RUG), LinkedIn

Good to know!
"Julien Es Sayed won the award for the best oral presentation by a young scientist at the 35th Conference of the European Colloid and Interface Society (ECIS) 2021 sponsored by Langmuir. He presented his work on the stabilization/breaking emulsions with supramolecular microgels" @SIMM_Lab

Dr. Emma Hinderink

Postdoc Chemical Engineering at the Faculty of Applied Science, TU Delft

Presentation
Dynamic processes occurring during emulsion production: Insights from a microfluidic approach (Pdf file, 2 MB)

Abstract
To understand the phenomena occurring during emulsification and downstream processing, effects that take place at the micron- and sub-second time scales need to be investigated. Emulsifiers are typically used to stabilise the newly formed droplets. Dependent on the type of emulsifier used, a viscoelastic interface layer may form that protects droplets against coalescence. Whether such a network, or at least its initial states, is already formed during production is instrumental to understand droplet stabilisation immediately after droplet formation. After emulsification, emulsions are further processed. During downstream processing emulsion droplets are subjected to non-uniform flows. Within such a flow, emulsion droplets can deform, break-up and coalesce, therewith affecting final product properties. At high dispersed phase fractions, one local coalescence event can propagate leading to a cascade of coalescence events therewith destabilising part of the entire droplet assembly. In this presentation, I introduce various microfluidic devices that enable to study emulsion stability and interfacial properties at the droplet level and at time scales relevant to industrial processes. Microfluidic experiments are combined with state-of-the-arte micro-particle tracking velocimetry to unravel the dynamic interplay between fluid flow and stability.

References

Emma Hinderink is mixing the immiscible (read the interview!) at Delft University of Technology.

Find her at LinkedIn, Research Gate, and Google Scholar!

Dr. Janne-Mieke Meijer

Assistant Professor in the Theory of Polymers & Soft Matter group, Applied Physics, TU Eindhoven

Presentation
Complex colloidal self-assembly: towards designer materials (Pdf file, 5 MB)

Abstract
To develop new materials with novel mechanical, optical or electronic functionalities control over matter on multiple length scales is needed. One of the most promising design strategies in material science is leveraging the spontaneously self-organization of molecular, nanoparticle and colloidal building blocks into larger complex superstructures. However, not all potential of these materials is currently exploited is because control over the self-assembly of the building blocks into the desired predesigned structures is still lacking. In this talk I will show how studying colloidal self-assembly with both quantitative microscopy and x-ray scattering techniques is uniquely powerful for visualizing the self-assembly on a single-particle level. I will address the influence of shape anisotropy as well as directed self-assembly on the final superstructures and defect dynamics. I will further show how by employing complex colloids we can gain new insights of the fundamental forces, mechanics and design principles that govern their self-assembly.

"Colloids are not only fun to study but also beautiful", and therefore, instagrammable!
Follow Janne-Mieke Meijer: @JMs_colloids

http://www.janne-miekemeijer.com/

Dr. Julieta Paez

Assistant Professor, Developmental BioEngineering, Faculty of Science and Technology, UTwente
Title: Biomedical applications of bioinspired dynamic hydrogels

Abstract
Cell-encapsulating hydrogels are used as extracellular matrix mimics for tissue engineering applications. For synthetic hydrogels to mimic the native cell microenvironment more closely, molecular engineering aims at pre-programming smart properties in the design of these materials. One approach is the use of versatile coupling chemistries to engineer the network crosslinks. This allows to control basic properties in the system such as gelation rate, mechanics and bioactivity; and to confer advanced properties like self-healing, stimuli-responsiveness and adaptability.

I will present the use of bioinspired chemistry to molecularly engineer hydrogels with tunable viscoelastic properties for cell encapsulation. In a first molecular design, bioinspired covalent chemistry enables the fabrication of tunable and inexpensive hydrogels for 3D cell culture [1]. This platform exhibits advantages like rapid gelation rate and tunability of mechanical and biological properties. In a second molecular design, redox-responsive hydrogels widen the application range of this synthetic platform [2], by enabling to finely control the gelation onset and gelation rate, which can be used to modulate the injectability of these materials. Finally, I will present the development of reversible hydrogels with self-healing and stress-relaxing properties [3]. These bioinspired hydrogels are a robust and versatile platform for cell culture, enabling easy adjustment of properties to perform in diverse biomedical scenarios.

References

ResearchGate profile of Julieta Paz

Follow our speakers on Twitter:

Julieta Paez @PaezLab
Janne-Mieke Meijer @JenneMikie
Georgy Filonenko @GeorgyFilonenko
Siddharth Deshpande @SiddhuLab
Physical Chemistry & Soft Matter (WUR) @PCC_WUR

Prof.dr.ir. Atze Jan van der Goot

Professor Sustainable Protein Technology, Food Process Engineering (WUR)
Title: Structuring of Food Products. What can we learn from soft matter physics?

Abstract
The creation of anisotropic and fibrous food products will be presented. These products can form the basis for next generation meat analogues. Meat analogues are made from plant and diary proteins, which can be transformed into anisotropic products when deformed in a well defined manner. However, not all proteins have the right properties to form anisotropic products. Here soft matter physics can help to better understand why certain proteins or protein aggregates form anisotropic products or others not. In addition, it can help to better understand protein-water interactions, which is essential to better control the texture properties of these products as well as their juiciness. Finally, developments will be highlighted of new analytical tools to quantify the anisotropy of these products.


References

    

Plenary discussions

Wrapping up each session with a plenary discussion.


Wiebe de Vos, Georgy A. Filonenko, Armin Amirsadeghi, Siddharth Deshpande

Karin Schro√ęn (chair), Jasper van der Gucht, Emma Hinderink, Julien Es Sayed

Janne-Mieke Meijer, Julieta Paez, Atze Jan van der Goot

Chairs

Prof.dr.ir. Karin Schroën
Professor of Food Process Engineering (WUR) and part-time professor of Membrane Processes for Food (UTwente)
Prof.dr.ir. Arjan Mol
Professor Corrosion Technology and Electrochemistry (TU Delft) and Scientific Director (4TU.HTM)